Septo–hippocampal interaction
نویسندگان
چکیده
منابع مشابه
Gene-experience interaction alters the cholinergic septohippocampal pathway of mice.
Spatial learning requires the septohippocampal pathway. The interaction of learning experience with gene products to modulate the function of a pathway may underlie use-dependent plasticity. The regulated release of nerve growth factor (NGF) from hippocampal cultures and hippocampus, as well as its actions on cholinergic septal neurons, suggest it as a candidate protein to interact with a learn...
متن کاملThe Role of the Septohippocampal Cholinergic System in Cognitive Functions
Cholinergic dysfunction is a hallmark of Alzheimer’s disease (AD). This dysfunction is assumed to be mainly responsible for the cognitive defects in AD. However, the mechanism by which the cholinergic system regulates cognitive functions is elusive. This study was designed to find out the role of the septohippocampal cholinergic system in cognitive functions. The methods used were behavioural t...
متن کاملThe septohippocampal system participates in general anesthesia.
How the brain mediates general anesthesia is not known. We report that two interconnected structures in the forebrain, the medial septum and the hippocampus, participate in maintaining awareness and movements during general anesthesia. In the awake, freely behaving rat, inactivation of the medial septum or the hippocampus by local injection of a GABA(A) receptor agonist, muscimol, decreased the...
متن کاملHypocretin/orexin innervation and excitation of identified septohippocampal cholinergic neurons.
Hypothalamic fibers containing the wake-promoting peptides, hypocretins (Hcrts) or orexins, provide a dense innervation to the medial septum-diagonal band of Broca (MSDB), a sleep-associated brain region that has been suggested to show intense axonal degeneration in canine narcoleptics. The MSDB, via its cholinergic and GABAergic projections to the hippocampus, controls the hippocampal theta rh...
متن کاملGABAergic septohippocampal neurons are not necessary for spatial memory.
The medial septum/vertical limb of the diagonal band of Broca (MSDB) provides a major input to the hippocampus and is important for spatial memory. Both cholinergic and GABAergic MSDB neurons project to the hippocampus, and nonselective lesions of the MSDB or transections of the septohippocampal pathway impair spatial memory. However, selective lesions of cholinergic MSDB neurons using 192-IgG ...
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ژورنال
عنوان ژورنال: Cell and Tissue Research
سال: 2017
ISSN: 0302-766X,1432-0878
DOI: 10.1007/s00441-017-2745-2